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AJNR - American Journal of Neuroradiology

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[¹¹C]Methionine PET, Histopathology, and Survival in Primary Brain Tumors and Recurrence

S. Ceyssens^a, K. Van Laere^a, T. de Groot^b, J. Goffin^c, G. Bormans^b and L. Mortelmans^a

^a Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
^b Laboratory of Radiopharmaceutical Chemistry, University Hospital Leuven, Leuven, Belgium
^c Department of Neurosurgery, University Hospital Leuven, Leuven, Belgium

View larger version (9K): [in a new window]   Fig 1. Tumor uptake index for the group of patients on primary staging and for the patients with suspected brain tumor recurrence or progression after primary therapy. Boxes show 1 SD from the mean value; whiskers show the 95% confidence interval limits. There was no significant difference in uptake between both groups.

View larger version (13K): [in a new window]   Fig 2. [11C]Methionine maximum uptake index as a function of grading. Grading values are regrouped as indicated in the text. Grade 0' (benign) and grade I' (WHO grade I and intermediate grade I–II) show significantly reduced uptake compared with grade II'–IV' lesions. Box plots show the mean value, and whiskers show the 95% confidence interval limits. Boxes show 1 SE; whiskers show the 95% confidence interval limits.

View larger version (64K): [in a new window]   Fig 3. Example of [11C]methionine PET of a patient with a grade I–II tumor (woman, 31 years old, oligodendroglioma in follow-up) (A) and a patient with a grade IV tumor (woman, 33 years old, glioblastoma multiforme in follow-up), showing comparable tracer uptake (B).

View larger version (15K): [in a new window]   Fig 4. Kaplan-Meier (cumulative proportion surviving) curves for WHO low-grade versus high-grade tumors. , death; "+" values (patients lost to follow-up).