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[11C]Methionine PET, Histopathology, and Survival in Primary Brain Tumors and Recurrence

S. Ceyssensa, K. Van Laerea, T. de Grootb, J. Goffinc, G. Bormansb and L. Mortelmansa

a Division of Nuclear Medicine, University Hospital Leuven, Leuven, Belgium
b Laboratory of Radiopharmaceutical Chemistry, University Hospital Leuven, Leuven, Belgium
c Department of Neurosurgery, University Hospital Leuven, Leuven, Belgium


Figure 1
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  		Fig 1. Tumor uptake index for the group of patients on primary staging and for the patients with suspected brain tumor recurrence or progression after primary therapy. Boxes show 1 SD from the mean value; whiskers show the 95% confidence interval limits. There was no significant difference in uptake between both groups.


Figure 2
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  		Fig 2. [11C]Methionine maximum uptake index as a function of grading. Grading values are regrouped as indicated in the text. Grade 0' (benign) and grade I' (WHO grade I and intermediate grade I–II) show significantly reduced uptake compared with grade II'–IV' lesions. Box plots show the mean value, and whiskers show the 95% confidence interval limits. Boxes show 1 SE; whiskers show the 95% confidence interval limits.


Figure 3
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  		Fig 3. Example of [11C]methionine PET of a patient with a grade I–II tumor (woman, 31 years old, oligodendroglioma in follow-up) (A) and a patient with a grade IV tumor (woman, 33 years old, glioblastoma multiforme in follow-up), showing comparable tracer uptake (B).


Figure 4
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  		Fig 4. Kaplan-Meier (cumulative proportion surviving) curves for WHO low-grade versus high-grade tumors. {circ}, death; "+" values (patients lost to follow-up).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X