AJDRAJNR - American Journal of Neuroradiology

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Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment

F.L. Giesela,d, H.K. Hahnb, P.A. Thomannc, E. Widjajad, E. Wignalld, H. von Tengg-Kobligka, J. Pantelc, P.D. Griffithsd, H.O. Peitgenb, J. Schrodere and M. Essiga

a German Cancer Research Center, Heidelberg, Germany
b MeVis–Center for Medical Diagnostic System and Visualization, Bremen, Germany
c Section for Geriatric Psychiatry, University of Heidelberg, Germany
d Section of Academic Radiology, University of Sheffield, United Kingdom
e Department of Psychiatr, University of Frankfurt, Germany


Figure 1
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Fig 1. Posterior limit of temporal horns defined by a cut plane through 3 distinct anatomic landmarks that can be defined reliably and independently of patient positioning or head rotation, respectively.


Figure 2
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Fig 2. 3D appearance of the ventricles in a control subject (A), subject with MCI (B), and a patient with AD (C). The temporal horn of the lateral ventricle is larger in the patient with AD compared with the control subject or patient with MCI.


Figure 3
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Fig 3. Significant negative correlation between the THV/THI and neuropsychologic test (P < .01). THI = Neuropsychologic test = 7.45 ± 15.75 x tthi R2 = 0.29; THV = Neuropsychologic test = 7.12 32 ± 0.67 x tthv R2 = 0.44.