Temporal Horn Index and Volume of Medial Temporal Lobe Atrophy Using a New Semiautomated Method for Rapid and Precise Assessment
F.L. Giesela,d,
H.K. Hahnb,
P.A. Thomannc,
E. Widjajad,
E. Wignalld,
H. von Tengg-Kobligka,
J. Pantelc,
P.D. Griffithsd,
H.O. Peitgenb,
J. Schrodere and
M. Essiga
a German Cancer Research Center, Heidelberg, Germany
b MeVisCenter for Medical Diagnostic System and Visualization, Bremen, Germany
c Section for Geriatric Psychiatry, University of Heidelberg, Germany
d Section of Academic Radiology, University of Sheffield, United Kingdom
e Department of Psychiatr, University of Frankfurt, Germany

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Fig 1. Posterior limit of temporal horns defined by a cut plane through 3 distinct anatomic landmarks that can be defined reliably and independently of patient positioning or head rotation, respectively.
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Fig 2. 3D appearance of the ventricles in a control subject (A), subject with MCI (B), and a patient with AD (C). The temporal horn of the lateral ventricle is larger in the patient with AD compared with the control subject or patient with MCI.
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Fig 3. Significant negative correlation between the THV/THI and neuropsychologic test (P < .01). THI = Neuropsychologic test = 7.45 ± 15.75 x tthi R2 = 0.29; THV = Neuropsychologic test = 7.12 32 ± 0.67 x tthv R2 = 0.44.
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