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AJNR - American Journal of Neuroradiology

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Functional Brain Imaging Using a Long Intravenous Half-Life Gadolinium-Based Contrast Agent

D.W. Morton^a, B. Keogh^a, K. Lim^a and K.R. Maravilla^a

^a From the Department of Radiology, University of Washington, Seattle, Wash

View larger version (63K): [in a new window]   Fig 1. BOLD fMRI (A) and MS-325 fMRI (B) response to forepaw stimulation. All data are from the same experiment in the same animal. BOLD fMRI was performed first. Then 0.1 mmol/kg MS-325 was administered intravenously and the MS-325 fMRI measurement was then performed. Top row, activation maps for BOLD fMRI (left) and MS-325 fMRI (right). Arrows indicate the voxel with the highest Z score in each measurement. Bottom row, time series data from the most active voxels (indicated by arrows in top row) for BOLD (left) and MS-325 (right) fMRI. Double arrow lines (C and D) indicate activation amplitude for BOLD and MS-325 data in the most significantly active voxel. Asterisk indicates flow-related enhancement in the superior sagittal sinus that is not related to activation.

View larger version (10K): [in a new window]   Fig 2. Average distance (millimeters) between the most active voxel in BOLD fMRI measurements versus the location of the most active voxel in MS-325 fMRI in the same animal (n = 9). The distances (x, y, and z) between the most active voxels were determined for each animal. Data are displayed as mean millimeters ± SD.