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AJNR - American Journal of Neuroradiology

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A Functional MRI Study: Cerebral Laterality for Lexical-Semantic Processing and Human Voice Perception

M. Koeda^a, H. Takahashi^c, N. Yahata^d, K. Asai^f, Y. Okubo^e and H. Tanaka^a,

^a Department of Bioinformatics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
^b Department of Bioinformatics and Computational Biology, School of Biomedical Sciences, Tokyo Medical and Dental University, Tokyo, Japan
^c National Institute of Radiological Sciences Brain Imaging Project, Chiba, Japan
^d Departments of Pharmacology, Nippon Medical School, Tokyo, Japan
^e Neuropsychiatry, Nippon Medical School, Tokyo, Japan
^f Asai Hospital, Togane, Japan

View larger version (39K): [in a new window]   Fig. 1. A, reverse sentences (rSEN); B, identifiable nonvocal sounds (SND). C, sentences (SEN).

View larger version (61K): [in a new window]   Fig. 2. Activated areas revealed by the contrasts. rSEN-SND (A), SEN-SND (B), and SEN-rSEN (C) with a statistical threshold of P < .00005 (random effect model uncorrected; extent threshold at 10 voxels). SEN, sentences; rSEN, reverse sentences; SND, identifiable nonvocal sounds.

View larger version (15K): [in a new window]   Fig. 3. LI distribution of the temporal activation under rSEN-SND, SEN-SND, and SEN-rSEN contrasts: The bold line shows the mean of LI under each contrast. One-way ANOVA and multiple comparison by Bonferroni test for individual LI in temporal activation was significantly different among the 3 contrasts (ANOVA: F (2, 78) = 26.28, P < .001, Bonferroni: P < .05). *, P < .05; **, P < .001.

View larger version (53K): [in a new window]   Fig. 4. Individual variability of LI of the temporal cortices: symmetrical or right-lateralized activation was observed in 22 of 27 subjects (81.4%) under the rSEN-SND contrast in the temporal cortices. Although 9 of 27 subjects (33.3%) showed symmetrical or right-lateralized activation under the SEN-SND contrast in the temporal cortices, all subjects showed left hemisphere dominance under the SEN-rSEN contrast. *, P < .05; **, P < .001.