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AJNR - American Journal of Neuroradiology

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Proton MR Spectroscopy in Neonates with Perinatal Cerebral Hypoxic-Ischemic Injury: Metabolite Peak-Area Ratios, Relaxation Times, and Absolute Concentrations

J.L.Y. Cheong^a, E.B. Cady^b, J. Penrice^a, J.S. Wyatt^a, I.J. Cox^c and N.J. Robertson^d

^a Department of Paediatrics and Child Health, University College London, London, UK
^b Department of Medical Physics and Bio-Engineering, University College London Hospitals NHS Trust, London, UK
^c Imaging Sciences Department, Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
^d Department of Obstetrics and Gynaecology, University College London, London, UK

View larger version (139K): [in a new window]   Fig 1. Voxel positioning. An axial scout image was obtained and an orthogonal medial sagittal section positioned (A); the 8-mL cubic PRESS voxel was then centered on the thalami and the midline by using the sagittal image (B).

View larger version (16K): [in a new window]   Fig 2. Representative brain spectra from a control infant and 2 neonates with neonatal encephalopathy acquired from an 8-mL voxel centered on the thalami by using PRESS (TE, 270 ms; and TR, 2 seconds). The dashed lines are the spectrum analysis Lorentzian profiles fitted to the peaks. A, Control. B, Normal/mild outcome. C, Severe/fatal outcome.