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Hippocampal Atrophy Confounds Template-Based Functional MR Imaging Measures of Hippocampal Activation in Patients with Mild Cognitive Impairment

C.K. Sandstroma, S. Krishnana, M.J. Slavinc, T.-T.T. Trana, P.M. Doraiswamyb and J.R. Petrellaa

a Department of Radiology, Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC
b Departments of Psychiatry and Medicine (Geriatrics), University of New South Wales, Sydney, NSW, Australia
c School of Psychiatry, University of New South Wales, Sydney, NSW, Australia


Figure 1
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  		Fig 1. A, Hippocampal ROI (from WFU PickAtlas31–33) on the MNI template.11

B, Seventy-five-year-old man with MCI, with hippocampal ROI drawn manually on image.


Figure 2
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  		Fig 2. Correlation of right hippocampal activation in a template-space-based ROI with right hippocampal volume in subjects with MCI and control subjects during retrieval. Hippocampal volumes have been normalized by single-section intracranial area and hippocampal activation has been adjusted for subject age. Units of activation are represented as proportion of ROI activated. The line demonstrates a significant negative correlation between hippocampal volume and activation in the subjects with MCI.


Figure 3
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  		Fig 3. Correlation of right hippocampal activation in a native-space-based manual ROI with right hippocampal volume in subjects with MCI and control subjects during retrieval. Hippocampal volumes have been normalized by single-section intracranial area and hippocampal activation has been adjusted for subject age. Units of activation are represented as proportion of ROI activated.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X