Assessment of White Matter Damage in Subacute Sclerosing Panencephalitis Using Quantitative Diffusion Tensor MR Imaging
R. Trivedia,
R.K. Guptaa,
A. Agarawalc,
K.M. Hasane,
A. Guptaa,
K.N. Prasadb,
G. Bayud,
D. Rathored,
R.K.S. Rathored and
P.A. Narayanae
a Department of Radiodiagnosis
Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
b Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, UP, India
c Department of Neurology, King George Medical University, Lucknow, UP, India
d Department of Mathematics, Indian Institute of Technology, Kanpur, UP, India
e Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, Houston, Tex
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Fig 1. A 6-year-old healthy control. T2-weighted (A), FA (B), and color-coded FA images fused with apparent diffusion coefficient (ADC) maps (C) through the lateral ventricles show normal distribution of white matter. The rectangular and elliptic ROIs are placed (C) on the frontal, parietal, and occipital cerebral lobes and the posterior limb of the internal capsule for quantification of FA and MD values. The cutoff value for the color-coded FA for display is kept at 0.2 (C), above which the color-coded regions reflect the white matter only (red [right–left)], green [anteroposterior], and blue [superior–inferior)]).
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Fig 2. A 12-year-old boy with clinical findings of SSPE shows normal appearance on the T2-weighted image (A). FA map (B) shows bilateral significantly low FA values in the white matter (right frontal white matter, 0.15; left frontal white matter, 0.18; right parietal white matter, 0.16; left parietal white matter, 0.15; right occipital white matter, 0.17; left occipital white matter, 0.12). Color-coded FA fused with the ADC map (C) shows the abnormality more clearly.
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Fig 3. A 7-year-old boy with SSPE has hyperintensities on the T2-weighted (A) image (arrow) in the right frontal and parietooccipital region. The FA map (B) shows widespread bilateral abnormal white matter (right frontal white matter, 0.06; left frontal white matter, 0.14; right parietal white matter, 0.09; left parietal white matter, 0.13; right occipital white matter, 0.12; left occipital white matter, 0.17) and thinning of the genu and splenium of the corpus callosum. Color-coded FA fused with the ADC map (C) shows the abnormality more clearly.
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