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Parry-Romberg Syndrome with a Clinically Silent White Matter Lesion

A. Okumuraa, T. Ikutaa, T. Tsujia, T. Katoa, H. Fukatsub, S. Naganawab, K. Katob and K. Watanabec

a Department of Pediatrics, Nagoya University Graduate School of Medicine, Aichi, Japan
b Department of Radiology, Nagoya University Graduate School of Medicine, Aichi, Japan
c Faculty of Medical Welfare, Aichi Shukutoku University, Aichi, Japan


Figure 1
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Fig 1. Photograph, CT, and MR imaging of the patient. A, Photograph at 34 months of age. Skin and soft-tissue atrophy of the left periorbital and premaxillary areas are recognized. B, CT scan obtained at 34 months of age. Low attenuation is shown in the entire white matter in the left hemisphere. C, FLAIR image obtained at 44 months of age. Abnormal high-intensity areas are observed in the entire white matter in the left hemisphere and in the occipital region in the right hemisphere. Small cysts are seen in the bilateral deep white matter. D, FA map. Decrease of anisotropy is observed in the white matter in the left hemisphere. E, Tractography of pyramidal tracts. Pyramidal tracts are clearly depicted in both hemispheres. F, Tractography of optic radiations, which are also depicted symmetrically.


Figure 2
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Fig 2. SPECT findings. Blood perfusion is decreased in the white matter in the left hemisphere, whereas it is increased in the cerebral cortex in the ipsilateral hemisphere.


Figure 3
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Fig 3. Proton MR spectroscopy. Normal spectral patterns are observed in both hemispheres.