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Effects of Number of Diffusion Gradient Directions on Derived Diffusion Tensor Imaging Indices in Human Brain

H. Nia, V. Kavcicb, T. Zhuc, S. Ekholma and J. Zhonga,c

a Department of Radiology, University of Rochester Medical Center, Rochester, NY
b Department of Neurology, University of Rochester Medical Center, Rochester, NY
c Department of Biomedical Engineering, University of Rochester Medical Center, Rochester, NY


Figure 1
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Fig 1. A, An example of coregistration across 3 protocols. Images on the left, middle, and right are obtained with the 6-NDGD, 21-NDGD, and 31-NDGD protocols, respectively. A region of interest (ROI) of the splenium of CC is initially drawn on only 1 image from 1 of the 3 protocols and then translated to the corresponding images from the other 2 protocols.

B, Spatial definition of ROIs: all ROIs are positioned relative to CC in the anterior (A, CCA), middle [B, CCM, cingulum (D), SLF (E), and IC (F)], and posterior [C, CCP, cingulum (D), and SLF (E)] locations.


Figure 2
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Fig 2. Mean value in 6 ROIs for the 3 protocols; A for FA, B for <D>, C for {lambda}1, D for {lambda}2, and E for {lambda}3. <D>, {lambda}1, {lambda}2, and {lambda}3 are measured in 10–3 mm2/s. White bars for 6-NDGD, gray bars for 21-NDGD, and black bars for 31-NDGD protocols. *, P < .05. Error bars are for 1 SEM.


Figure 3
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Fig 3. Correlation coefficient (r) in 6 ROIs between 2 of the 3 protocols. A for FA, B for <D>, C for {lambda}1, D for {lambda}2, and E for {lambda}3. White bars are for r6–21, gray bars for r6–31, and black bars for r21–31. *, P < .05. Error bars are for 1 SEM.


Figure 4
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Fig 4. The linear fitting between correlation coefficient of FA versus FA value of different ROIs.