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First Results in an MR Imaging-Compatible Canine Model of Acute Stroke

A. Shaibania, S. Khawara, W. Shinb, T.A. Cashenb, B. Schirfa, M. Rohanya, S. Kakodkara and T.J. Carrolla,b

a Department of Radiology, Northwestern University, Chicago, Ill
b Department of Biomedical Engineering, Northwestern University, Chicago, Ill


Figure 1
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  		Fig 1. Right internal carotid artery injection delineating the canine circle of Willis (A) before and (B) after injection of an autologous blood clot. Note the conspicuous absence of the middle cerebral artery on the right side after the injection confirming the stroke.


Figure 2
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  		Fig 2. The evolution of the stroke as demonstrated by water diffusion changes in 2 coronal sections acquired in the first hour post ictus. b = 1000 images (A) and ADC images (B) demonstrate the increased diffusion contrast and reduced ADC in the region affected by the stroke (arrows).


Figure 3
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  		Fig 3. A, An image of quantitative CBF acquired 30 minutes post ictus demonstrates a large region of hypoperfusion (qCBF <10 mL/100 g-min) in the left MCA territory.

B, Diffusion-weighted images (b = 1000) acquired after 2 hours show that, in this case, the territory of hypoperfusion observed immediately after the stroke goes on to become a pronounced diffusion abnormality.

C, ADC values confirm the region of diffusion seen in the b = 1000 image.


Figure 4
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  		Fig 4. Thrombolysis achieved partial restoration of cerebral perfusion in 1 animal.

A, Pretreatment time to peak of a single coronal section demonstrates a large region of prolonged TTP in the left MCA territory (arrows).

B, The ADC image acquired at 2 hours confirms a region of reduced ADC.

C, The corresponding TTP acquired upon completion of the infusion of rtPA shows marked improvement of flow in the affected territory. Quantitative flow images calculated before (D) and after (E) treatment show that qCBF in the region affected by the stroke has been restored to a value that is above the known threshold for ischemic stroke.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X