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Not All Age-Related White Matter Hyperintensities Are the Same: A Magnetization Transfer Imaging Study

A. Spilta, R. Goekoopc, R.G.J. Westendorpb, G.J. Blauwb, A.J.M. de Craenb and M.A. van Buchema

a Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands
b Department of General Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands
c Department of Neurology, Alzheimer Center, VU University Medical Center, Amsterdam, the Netherlands


Figure 1
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  		Fig 1. Different types of PVWMH. Examples of frontal PVWMH with a smooth lining (A, right and left) and frontal PVWMH with an irregular lining (B, right and left) and examples of occipital PVWMH with smooth (C, right) and irregular (D, right and left) linings.


Figure 2
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  		Fig 2. Example of a PVWMH with the characteristic high signal intensity on a T2-weighted image (A) with a low signal intensity on a T1-weighted image (B) (arrow).


Figure 3
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  		Fig 3. Example of an image from the MTI protocol, obtained with saturation pulse (Ms) and having a proton-attenuation weighted contrast. It clearly shows occipital periventricular white matter hyperintensities as well as deep white matter hyperintensities.


Figure 4
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  		Fig 4. Mean MTRs with 95% confidence intervals for the 4 different regions in the subjects with white matter hyperintensities.


Figure 5
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  		Fig 5. Subject (8-year-old) with an obstructive hydrocephalus secondary to infratentorial mass before (A, T1-weighted image; C, T2-weighted image) and after placement of a ventriculoperitoneal shunt (B, T1-weighted image; D, T2-weighted image). Notice the location and lining of the areas with increased signal intensity hypointensities on T1-weighted images in the periventricular white matter before drainage (A), disappearing after drainage (B).





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X