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Transient Splenial Lesion of the Corpus Callosum in Clinically Mild Influenza-Associated Encephalitis/Encephalopathy

N. Bulakbasia, M. Kocaoglua, C. Tayfuna and T. Ucoza

a From the Department of Radiology, Gulhane Military Medical Academy, Ankara, Turkey


Figure 1
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  		Fig 1. Patient 1 (21 years old) with IAEE and sudden onset of facial numbness and left upper monoparesis on day 5. A, Axial T2-weighted image shows a hyperintense well-defined and circumscribed splenial lesion (arrowheads). B, Axial T2-weighted image through the supraventricular region shows patchy high signal intensity of deep white matter lesions (arrows). C and D, Splenial (arrowheads) and deep white matter (arrows) lesions have higher signal intensity on isotropic DWI than those on T2-weighted images. E and F, ADC map images reveal significant restricted diffusion with reduced ADC values obtained from 3 regions of interest of splenial and white matter lesions (0.42 ± 10–3 mm2/s, 0.47 ± 10–3 mm2/s, and 0.51 ± 10–3 mm2/s). G and H, Follow-up isotropic DWI on day 11 shows the reversal of diffusion restriction in both splenial and white matter lesions.


Figure 2
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  		Fig 2. Patient 4 (6 years old) with IAEE and fever and sudden-onset convulsion on day 3. A, Single ovoid well-defined splenial lesion (arrowheads) is slightly hyperintense on the T2-weighted axial image. B, The lesion (arrowheads) has prominently high signal intensity on isotropic DWI. C, ADC value of 0.34 ± 10–3 mm2/s obtained from the region of interest located in the lesion reveals restricted diffusion on ADC map image. D, Follow-up study on day 9 shows complete resolution of diffusion restriction on isotropic DWI.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X