AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on October 9, 2007
doi: 10.3174/ajnr.A0687
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Lobar Distribution of Changes in Gray Matter and White Matter in Memory Clinic Patients: Detected Using Magnetization Transfer Imaging

A.C.G.M. van Esa, W.M. van der Fliere, F. Admiraal–Behlould, H. Olofsend, E.L.E.M. Bollenb, H.A.M. Middelkoopb, A.W.E. Weverling-Rijnsburgerc, J. van der Gronda, R.G.J. Westendorpc and M.A. van Buchema

a Departments of Radiology, Leiden University Medical Center, Leiden, the Netherlands
b Neurology, Leiden University Medical Center, Leiden, the Netherlands
c Section of Gerontology and Geriatrics of the Department of General Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands
d Section of Image Processing of the Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands, Leiden University Medical Center, Leiden, the Netherlands
e Department of Neurology and Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, the Netherlands


Figure 1
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  		Fig 1. A, Automatic segmentation process. First, the PD image is used to create an intracranial segmentation. B, The PD, T2, and FLAIR images are combined to generate segmentations of GM and WM. C, After that, the masks are coregistered to the MTI image. D, Finally, the custom template representing the frontal, parietal, temporal, and occipital lobes, drawn according to Zilles and Rehkämper,24 was applied (also see Fig 2).


Figure 2
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  		Fig 2. 3D example of the anatomic template used in this study. The boundaries between the lobes in this template were drawn according to Zilles and Rehkämper.24


Figure 3
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  		Fig 3. Scatterplot of MMSE versus temporal GM peak height (Pearson r = 0.67). In a linear regression analysis with the GM and WM peak heights of all lobes, WMH volume, atrophy, age, and sex as predictors, temporal GM peak height was, along with age, the only parameter to independently predict MMSE (P < .001; ß[SE] = 0.75 [.03]). This implies that if the MMSE decreases 1 point, the peak height will decrease with 0.75. {blacktriangleup} indicates cognitive normal; {square}, MCI; x, AD; MMSE, points scored on Mini Mental State Examination; Temporal GM Normalized Peak Height, number of voxels on the peak of the temporal GMMT histogram/total number of temporal GM voxels x 103.





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X