AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on September 28, 2007
doi: 10.3174/ajnr.A0700
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Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe

J. Huanga,b, R.P. Friedlandc and A.P. Auchusa,b

a Department of Neurology, University of Tennessee Health Science Center, Memphis, Tenn
b Research Services, Veterans Affairs Medical Center, Memphis, Tenn
c Department of Neurology, Case School of Medicine, Cleveland, Ohio


Figure 1
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  		Fig 1. Illustration of representative regions of interests positioned on T2-weighted echo-planar images (b = 0 s/mm2) in the NAWM of the frontal (A), temporal (B), parietal (C), and occipital lobes (D).


Figure 2
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  		Fig 2. Correlation of diffusion measurements with cognitive tests in all subjects. Poorer cognitive function is reflected by lower WLDR scores, higher TMT-B scores, and lower CP scores.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X