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AJNR - American Journal of Neuroradiology

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Whole-Brain and Regional Brain Atrophy in Amyotrophic Lateral Sclerosis

D.M. Mezzapesa^a, A. Ceccarelli^a, F. Dicuonzo^a, A. Carella^a, M.F. De Caro^a, M. Lopez^a, V. Samarelli^a, P. Livrea^a and I.L. Simone^a

^a From the Department of Neurological and Psychiatric Sciences, University of Bari, Bari, Italy

View larger version (64K): [in this window] [in a new window]   Fig 1. Regional cortical gray matter (GM) reduction in patients with amyotrophic lateral sclerosis (ALS) relative to healthy subjects (HS). Significant voxels are superimposed on selected sections of spatially normalized MR images from a control subject. The main regions with lower GM volume were left middle temporal gyrus and the subgyral region (A), right inferior frontal gyrus (B), and frontal and temporal areas (C).