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AJNR - American Journal of Neuroradiology

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Reproducibility of Three Whole-Brain N-Acetylaspartate Decline Cohorts in Relapsing-Remitting Multiple Sclerosis

O. Gonen^a, T.A. Oberndorfer^a, M. Inglese^a, J.S. Babb^a, J. Herbert^b and R.I. Grossman^a

^a Department of Radiology, New York University School of Medicine, New York, NY
^b Department of Neurology, New York University School of Medicine, New York, NY

View larger version (8K): [in this window] [in a new window]   Fig 1. Dot-plot distribution of individual patients as a function of average rate of WBNAA decline per year of CD disease duration (R1), as defined by Equations (1) and (5a). The vertical dotted lines at R1 = 0 and 1.7 mmol/L/y partition the cohort into stable (), moderate (), and rapid () according to criteria defined in the text.23

View larger version (5K): [in this window] [in a new window]   Fig 2. Same as Fig 1, except that the average individual rates of WBNAA decline per year, R2, were estimated for disease duration from FS, Y2, as defined by Equations (2) and (5b). The vertical dotted lines at R1 = 0 and 1.7 mmol/L/y partition the cohort into stable (), moderate (), and rapid () decline rates according to criteria defined in the text.23

View larger version (12K): [in this window] [in a new window]   Fig 3. Individual WBNAA levels as a function of Y1 (from clinical diagnosis) of Equation (1) (labeled according to Fig 1). Solid lines are the regressions calculated for each subgroup. The dashed lines are the ±95% confidence intervals calculated for the subgroups of the previous cohort.23 Note how well the current regressions fit into the previous cohort’s confidence intervals.23

View larger version (12K): [in this window] [in a new window]   Fig 4. Individual WBNAA levels as a function of Y2 (from fist symptom) of Equation (2) (labeled according to Fig 2). Solid lines are regressions for each subgroup. The dashed lines are the ±95% confidence intervals calculated for the subgroups of the previous cohort.23 Note how well the regression lines for the current patients fit into the previous cohort’s confidence intervals.23