AJDRAJNR - American Journal of Neuroradiology

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Minati, L.
Right arrow Articles by Savoiardo, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Minati, L.
Right arrow Articles by Savoiardo, M.

Imaging Degeneration of the Substantia Nigra in Parkinson Disease with Inversion-Recovery MR Imaging

L. Minatia,b, M. Grisolib, F. Carellac, T. De Simoneb, M.G. Bruzzoneb and M. Savoiardob

a Scientific Direction Unit, Istituto Nazionale Neurologico "Carlo Besta," Milan, Italy
b Neuroradiology Department, Istituto Nazionale Neurologico "Carlo Besta," Milan, Italy
c First Neurology Department, Istituto Nazionale Neurologico "Carlo Besta," Milan, Italy


Figure 1
View larger version (54K):
[in this window]
[in a new window]

  		Fig 1. Positioning of the region of interest (ROI) for area measurement, drawn on the visible substantia nigra (A), and of the ROI for relative contrast measurement, drawn including the whole expected extension of the substantia nigra (B).


Figure 2
View larger version (76K):
[in this window]
[in a new window]

  		Fig 2. Appearance of GMS (left column), WMS (middle column), and difference images (GMS-WMS, right column) from an MC (2 upper rows) and a PD (2 lower rows). Reduced hypointensity of the substantia nigra is evident on the difference images from the patient.


Figure 3
View larger version (16K):
[in this window]
[in a new window]

  		Fig 3. Distribution of young controls, age-matched controls, and patients on a Cartesian quadrant, having as abscissa, the lateral/medial contrast ratio and as ordinate, the nigral/midbrain area ratio. Separation is not achieved; however, measurements from patients tend to cluster in the area corresponding to reduced nigral area and increased lateral-medial contrast. SN indicates substantia nigra.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X