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Monitoring of Acute Generalized Status Epilepticus Using Multilocal Diffusion MR Imaging: Early Prediction of Regional Neuronal Damage

T. Engelhorna, A. Hufnagelb, J. Weisec, M. Baehrc and A. Doerflera

a Department of Neuroradiology, University of Erlangen, Erlangen, Germany
b Department of Neurology, University of Essen, Essen, Germany
c Department of Neurology, University of Goettingen, Germany


Figure 1
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  		Fig 1. Neuronal cell loss in the ventral hippocampus and the parietal cortex 2 weeks after status epilepticus compared with control animals. Note drastically reduced neuronal attenuation in the CA1 region of the ventral hippocampus (vCA1) and, to a lesser extent, in the parietal cortex (PaCor) at 2 weeks. Arrows in higher magnifications point at CA1 neuronal cell layers displaying reduced neuronal attenuation and swollen or pyknotic cells as signs of ongoing neuronal degeneration.


Figure 2
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  		Fig 2. Regions of interest (ROIs) used for quantitative apparent diffusion coefficient analysis.

A, Representative diffusion-weighted MR image on which ROIs are outlined.

B, Schematic drawing of a rat brain at similar level with identical ROIs superimposed. ROIs were defined as: retrosplenial parietal and temporal cortex (RCp and RCt), pyriform cortex (PC), hippocampus (Hippo), thalamus (Thal), and amygdala (Amy).


Figure 3
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  		Fig 3. Averaged apparent diffusion coefficients in the retrosplenial parietal, temporal, and pyriform (basal) cortex, the thalamus, amygdala, and hippocampus of pilocarpine-treated animals before and within 120 minutes after pilocarpine-induced status epilepticus; * indicates P < 0.05 compared to baseline.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X