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A Diffusion Longitudinal MR Imaging Study in Normal-Appearing White Matter in Untreated Relapsing-Remitting Multiple Sclerosis

F.G. Garacia, V. Colangeloa, A. Ludovicia, F. Gaudielloa, S. Marzialia, D. Centonzeb, L. Boffab, G. Simonettia and R. Florisa

a Department of Diagnostic Imaging and Interventional Radiology, University of Tor Vergata, Rome, Italy
b Department of Neuroscience, University of Tor Vergata, Rome, Italy


Figure 1
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  		Fig 1. Example of ROIs of approximately 50 mm2 placed over the NAWM of the centrum semiovale and then superimposed on the ADC maps.


Figure 2
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  		Fig 2. Comparison of relapsing versus remitting versus control patients (mean ADC: 801 x 10–6 mm2/s ± 27; 760 x 10–6 mm2/s ± 43; 699 x 10–6 mm2/s ± 36 in relapsing, remitting, and controls respectively). Asterisk indicates P < .01 versus controls; number symbol, P < .05 versus remitting.


Figure 3
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  		Fig 3. Mean ADC values comparison of patient groups with different EDSS scores and controls (ADC: EDSS <2 versus EDSS ≥2, 748 ± 38 versus 787 ± 36 x 10–6 mm2/s; controls, 699 x 10–6 mm2/s ± 36). Asterisk indicates P < .01 versus controls.


Figure 4
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  		Fig 4. Comparison between patients participating in the longitudinal study during their relapsing and their remitting phase (mean ADC: relapsing, 787 ± 34; remitting, 737 ± 26 x 10–6 mm2/s; P < .01).





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X