Magnetization Transfer Ratio in Alzheimer Disease: Comparison with Volumetric Measurements
B.H. Ridhaa,d,
M.R. Symmsb,
D.J. Tozerc,
K.C. Stocktona,
C. Frosta,e,
M.M. Siddiquea,
E.B. Lewisa,
D.G. MacManusc,
P.A. Boulbyb,
G.J. Barkerf,
M.N. Rossora,d,
N.C. Foxa and
P.S. Toftsc
a Dementia Research Centre, Institute of Neurology, University College London, London, UK
b Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
c NMR Research Unit, Institute of Neurology, University College London, London, UK
d Division of Neuroscience and Mental Health, Imperial College London, London, UK
e Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
f King's College London, Institute of Psychiatry, Department of Clinical Neuroscience, Centre for Neuroimaging Sciences, London, UK
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Fig 1. Outlining volumes-of-interest in the coronal plane of magnetization transfer ratio maps of a patient with Alzheimer disease: left and right hippocampal and central pontine regions (A) and left and right parietal white matter regions (B).
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Fig 2. Receiver operating curves plotting the sensitivity and specificity of differentiating Alzheimer disease patients from control subjects by measuring adjusted volume, mean magnetization transfer ratio or both for whole brain (A) and hippocampal regions (B).
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Fig 3. Relationship between adjusted whole brain volume and MMSE score among patients with AD and control subjects. The line indicates the linear regression of adjusted whole brain volume on MMSE score among patients with AD (correlation coefficient = 0.47, P = .048).
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