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AJNR - American Journal of Neuroradiology

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The Normal Neonatal Brain: MR Imaging, Diffusion Tensor Imaging, and 3D MR Spectroscopy in Healthy Term Neonates

A.I. Bartha^a, K.R.L. Yap^a, S.P. Miller^a,b, R.J. Jeremy^b, M. Nishimoto^a, D.B. Vigneron^c, A.J. Barkovich^a,b,c and D.M. Ferriero^a,b

^a Departments of Neurology, University of California at San Francisco, Calif
^b Pediatrics, University of California at San Francisco, Calif
^c Radiology, University of California at San Francisco, Calif

View larger version (42K): [in this window] [in a new window]   Fig 1. Locations of regions of interest for MRS and DTI measurements are marked by rectangles as follows:) basal ganglia (1), thalami (2), calcarine cortex (3), optic radiations (4), corticospinal tracts (5), posterior white matter (6), frontal white matter (7). A, Squares showing region of interest locations from which proton spectra ratios were acquired and calculated by automated processing after the MR study of every neonate. B, Squares showing the regions of interest from which Dav, FA, and eigenvalues were calculated by automated processing.

View larger version (70K): [in this window] [in a new window]   Fig 2. 3D MR spectroscopy imaging on a single plane at the level of the basal ganglia illustrates the variation in maturity of metabolites in different regions of a healthy term neonate. Note that the thalami have the most mature spectra, with lowest choline and highest NAA peaks, and the frontal white matter has the least mature spectra.