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AJNR - American Journal of Neuroradiology

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Correlation of MR Imaging and MR Spectroscopy Findings with Cognitive Impairment in Mucopolysaccharidosis II

L. Vedolin^a, I.V.D. Schwartz^b,c, M. Komlos^a, A. Schuch^c, A.C. Puga^b, L.L.C. Pinto^b, A.P. Pires^b and R. Giugliani^b,c

^a Neuroradiology Department, Mãe de Deus Center and Hospital Mãe de Deus, Porto Alegre, Brazil
^b Medical Genetics Service, Hospital de Clínicas, Porto Alegre, Brazil
^c Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, Brazil

View larger version (120K): [in this window] [in a new window]   Fig 1. Example of the localization used for single-voxel imaging. Superimposed on an axial T2-weighted image, the white square shows the volume of brain tissue sampled by MR spectroscopy at the WM (right frontal lobe) and GM (posterior occipital cortex).

View larger version (30K): [in this window] [in a new window]   Fig 2. MR spectroscopy of a patient with MPS II and CI. There is elevation of the mIns/Cr ratio at the GM (A) and WM (B).

View larger version (28K): [in this window] [in a new window]   Fig 3. MR spectroscopy of a MPS II patient without CI. Compared with Fig 2, elevated mIns/Cr ratio at the GM (A) and WM (B) is no longer present.