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AJNR - American Journal of Neuroradiology

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Changes of CSF and Spinal Pathomorphology after High-Concentration Ozone Injection into the Subarachnoid Space: An Experimental Study in Pigs

J.L. Tian^a, J.S. Zhang^a, Y.Y. Xiao^a, J.T. Liu^a, B. Yang^a, J.K. Li^a and M. Yu^a

^a From the Department of Radiology, Chinese PLA General Hospital, Beijing, China

View larger version (78K): [in this window] [in a new window]   Fig 1. Sagittal FSE T2-weighted MR image (TR/TE, 4000/110 ms) scanned 30 minutes after ozone (10 mL, 90 µg/mL) injection into the subarachnoid space shows gas (white arrowheads) in the subarachnoid space. There are no signal intensity changes in the spinal cord.

View larger version (83K): [in this window] [in a new window]   Fig 2. Sagittal FSE T1-weighted contrast-enhanced MR image (TR/TE, 500/15 ms) scanned 1 week after ozone (10 mL, 90 µg/mL) injection into the subarachnoid space shows gas absorbed in the subarachnoid space. There is no abnormal enhancement in the spinal cord, dural sac, arachnoid, or nerve roots (white straight arrow) during the arterial phase. Aorta enhancement also can be seen (white curved arrow).

View larger version (52K): [in this window] [in a new window]   Fig 3. Animals were sacrificed 1 week after ozone (10 mL, 90 µg/mL) injection into the subarachnoid space, and the spinal cord was obtained. The appearance of the spinal cords is normal. There is no discoloring or tarnishing, and the vessel is vivid and visible.

View larger version (101K): [in this window] [in a new window]   Fig 4. Histologic sample from the spinal cord in the lumbar 5–6 level 1 week after injection shows no abnormal changes in the dura (Du), arachnoid (Ara), pia mater (Pia), nerve tracts, or nerve roots (H&E, original magnification, x40).