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AJNR - American Journal of Neuroradiology

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Multivoxel Proton MR Spectroscopy in Malformations of Cortical Development

C.C. Leite^a, L.T. Lucato^a, J.R. Sato^b, K.D. Valente^c and M.C.G. Otaduy^a

^a Department of Radiology, University of São Paulo School of Medicine, São Paulo, Brazil
^b Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil
^c Department of Psychiatry, University of São Paulo School of Medicine, São Paulo, Brazil

View larger version (53K): [in this window] [in a new window]   Fig 1. Axial inversion-recovery image (A) shows a subcortical heterotopia on the right side. Axial T2-weighted image (B) demonstrates the selected volumes of interest located at the MCD (1) and at the normal-appearing contralateral side (2). MR spectroscopy obtained from the volume of interest centered at the MCD (C) shows a decreased NAA/Cr. D, MR spectroscopy obtained from the NACS. E, MR spectroscopy obtained from the white matter in a control subject.

View larger version (90K): [in this window] [in a new window]   Fig 2. Axial T2-weighted images demonstrate the 4 selected volumes of interest in the inferior level (A) and also in the superior level (B).