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Metabolic Findings on 3T 1H-MR Spectroscopy in Peritumoral Brain Edema

R. Riccia, A. Baccia, V. Tugnolib, S. Battagliaa, M. Maffeia, R. Agatia and M. Leonardia

a Department of Neuroradiology, Bellaria Hospital, Bologna, Italy
b Department of Biochemistry "G. Moruzzi", University of Bologna, Bologna, Italy


Figure 1
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  		Fig 1. A T2-weighted FSE axial image of a normal brain.

A, Localized proton spectrum from the VOI (8 cm3) in the white matter of the left frontal region of 16 healthy volunteers, recorded with use of the PRESS sequence at 3T (TR, 2000 ms; TE, 35 ms). (NAA indicates N-acetylaspartate; Cho, choline-containing compounds; Cr, creatine and phosphocreatine; mIns, myo-inositol; Glx, glutamate plus glutamine.)

B, Location of voxel used for localized proton spectra in healthy volunteers. A T2-weighted FSE axial image (TR, 4200 ms; TE, 93 ms; NEX, 2).


Figure 2
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  		Fig 2. A glioblastoma in patient 3.

A, Localized proton spectrum of the edema surrounding the large temporofrontal glioblastoma. The NAA/Cr, NAA/Cho, Cho/Cr, and mIns/Cr ratios are in the normal range. The Glx/Cr ratio is increased to 2.2 (normal value, 1.8 ± 0.2). Glc (3.78 and 3.44 ppm), Lac, Lip, Val, Leu, Ile, and Ala are detected.

B, Axial FSE T2-weighted image (TR, 4200 ms; TE, 93 ms; NEX, 2) with the location of the voxel (6.4 cm3) in the edematous tissue.

C, Axial SE T1-weighted image (TR, 560 ms; TE, 18 ms) after administration of contrast agent. At this level, the upper part of the tumor can be seen.


Figure 3
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  		Fig 3. A meningioma in patient 12.

A, Localized proton spectrum of the edema surrounding the meningioma. The NAA/Cho, Cho/Cr, and mIns/Cr ratios are in the normal range. NAA/Cr is decreased to 1.4 (normal value, 1.8 ± 0.3), and Glx/Cr is increased to 2.5 (normal value, 1.8 ± 0.2). Glc, Lac, Lip, Val, Leu, and Ile are detected.

B, Axial FSE T2-weighted image (TR, 4200 ms; TE, 93 ms; NEX, 2) with the voxel (8 cm3) location in the edematous tissue.

C, Axial SE T1-weighted image (TR, 560 ms; TE, 18 ms) after administration of contrast agent with strong enhancement of the tumor.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X