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AJNR - American Journal of Neuroradiology

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Increasing Contrast Agent Concentration Improves Enhancement in First-Pass CT Perfusion

H.M. Silvennoinen^a, L.M. Hamberg^b, L. Valanne^a and G.J. Hunter^b

^a Department of Radiology-Neuroradiology, Helsinki University Central Hospital, Helsinki, Finland
^b Department of Radiology-Neuroradiology, Division of Imaging, University of Texas M.D. Anderson Cancer Center, Houston, Tex

View larger version (63K): [in this window] [in a new window]   Fig 1. The regions of interest (ROI) for an arterial input (ACA) and venous output (sagittal sinus) (A) and for gray matter and white matter (B). The corresponding time-concentration curves are presented in C, in which curve 1 indicates the artery and curve, 2 the vein, and in D, in which curve 3 indicates gray matter and curve 4, white matter.

View larger version (24K): [in this window] [in a new window]   Fig 2. Presented are the regression lines for each category of region of interest. There is a 25% increase in opacification for gray matter (A), 21% for white matter (B), 30% for the arterial input (C), and 12% for the venous output (D), between 300- and 400-mg/mL formulations of contrast agent.