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Low Choline Concentrations in Normal-Appearing White Matter of Patients with Multiple Sclerosis and Normal MR Imaging Brain Scans

M.C. Gustafssona, O. Dahlqvistb,d, J. Jaworskia, P. Lundbergb,c,d and A.-M.E. Landtbloma

a Division of Neurology, University Hospital, Linköping, Sweden
b Department of Radiation Physics, University Hospital, Linköping, Sweden
c Department of Radiology, University Hospital, Linköping, Sweden
d Center for Medical Imaging and Visualization, University Hospital, Linköping, Sweden


Figure 1
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  		Fig 1. A and B, Coronal brain images (radiologic orientation) showing the standard locations of the 4 actual spectroscopy voxels in a healthy volunteer.

C, The spectrum of voxel 1 (parietal right). Assignments: 1, Cr-CH2-; 2, Glu {alpha}/Gln {alpha}; 3, Gln (multiple from C2-C6); 4, mIns; 5, Gln (multiple from C2-C6); 6, scyllo-inositol; 7, Cho (CH3)3; 8, Cr (CH3); 9, NAA; 10, NAA; 11, Glu {gamma}/ß; 12, Gln {gamma}/ß; 13, NAAG-methyl; 14, NAA-methyl; 15, Lac CH3; 16, protein background ("baseline").


Figure 2
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  		Fig 2. A, B, and C, Spectra of WM voxels from 3 different control subjects.

D, E, and F, Spectra of WM voxels from 3 different patients. Vertical scale adjusted using the height of tNA.





Copyright © 2008 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X