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AJNR - American Journal of Neuroradiology

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Whole-Brain Histogram and Voxel-Based Analyses of Diffusion Tensor Imaging in Patients with Leukoaraiosis: Correlation with Motor and Cognitive Impairment

R. Della Nave^a, S. Foresti^a, A. Pratesi^a, A. Ginestroni^a, M. Inzitari^b, E. Salvadori^b, M. Giannelli^d, S. Diciotti^c, D. Inzitari^b and M. Mascalchi^a

^a From the Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy
^b Clinica Neurologica III, Department of Neurology and Psychiatry, University of Florence, Florence, Italy
^c Department of Electronics and Telecommunications, University of Florence, Florence, Italy
^d Department of Medical Physics, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy

View larger version (95K): [in this window] [in a new window]   Fig 1. A–D, Whole-brain MD (A) and FA (B) histograms in a patient with low (n = 2) visual score of LA (continuous line), as shown by corresponding FLAIR images (C), and in a patient with high (n = 6) visual score of LA (dashed line), as shown by corresponding FLAIR images (D). A and B, The patient with the higher visual score shows higher 50th percentile (85.9 vs. 84.7) and lower kurtosis and skewness of the MD histogram (A) and lower 50th percentile (0.165 vs. 0.226) and higher kurtosis and skewness of the FA histogram (B) compared to the patient with lower visual score.

View larger version (21K): [in this window] [in a new window]   Fig 2. A–C, SPM2 "glass brain" representation showing large clusters in the corpus callosum and pericallosal white matter of significant (P < 0.05, corrected for multiple comparison by false discovery rate method) correlation between increasing MD value and scores of motor deficit (usual gait velocity in A; SPPB in B) in patients with LA. Superimposition of the same cluster demonstrated in B onto T1 template (C).

View larger version (20K): [in this window] [in a new window]   Fig 3. A and B, SPM2 "glass brain" representation showing small clusters in the corpus callosum of significant (P < 0.05, corrected for multiple comparison by false discovery rate method) correlation using small volume correction between decreasing FA value and scores of motor deficit (usual gait velocity in A; SPPB in B) in patients with LA.