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AJNR - American Journal of Neuroradiology

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Combined Pituitary Hormone Deficiency and PROP-1 Mutation in Two Siblings: A Distinct MR Imaging Pattern of Pituitary Enlargement

L.L.F. do Amaral^a, R.M. Ferreira^a, N.P.F.D. Ferreira^a, R.A. Mendona^a, V.H.R. Marussi^a, J.L. da Cunha^b, B.R. Maaranduba^b and J.D. Medeiros^b

^a Department of Neuroradiology, Medimagem, Hospital Beneficência Portuguesa, São Paulo, Brazil
^b Department of Endocrinology, Hospital Brigadeiro, São Paulo, Brazil

View larger version (63K): [in this window] [in a new window]   Fig 1. Patient #1 (the older brother): MR examination performed in 2003 shows an enlarged adenohypophysis with slightly high signal intensity on T1-weighted images (A), striking hypointensity on T2-weighted image (B), and no significant enhancement after contrast infusion (C).

View larger version (120K): [in this window] [in a new window]   Fig 2. Patient #2 (the younger child): Her first MR examination reveals exactly the same imaging findings observed in the older brother (A–C). Examination performed 3 years later shows a slight regression in the size of the adenohypophysis, but it remains with the same striking hypointensity on T2-weighted image (D–F).