Axonal Damage But No Increased Glial Cell Activity in the Normal-Appearing White Matter of Patients with Clinically Isolated Syndromes Suggestive of Multiple Sclerosis Using High-Field Magnetic Resonance Spectroscopy
M.P. Wattjesa,
M. Harzheimb,
G.G. Lutterbeya,
L. Klotzb,
H.H. Schilda and
F. Träbera
a From the Department of Radiology/Neuroradiology, University of Bonn, Bonn, Germany
b Department of Neurology, University of Bonn, Bonn, Germany
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Fig 1. A, Axial T2-weighted and coronal and sagittal T1-weighted MR images from a healthy control, demonstrating the positioning of the voxel (white frame) within the NAWM.
B, 1H-MR spectroscopy spectrum from a healthy control (upper row), a patient with CIS (middle row), and a patient with MS (bottom row). Note the decreased concentrations of tNAA in both patients and increased concentrations of mIns, particularly in the MS patient when compared with the age-matched healthy control (arrows). CIS indicates clinically isolated syndrome; MS, multiple sclerosis; tNAA, summation of N-acetylaspartate and N-acetylaspartyl-glutamate; mIns, myo-inositol; Cho, choline; tCr, summation of creatine and phosphor-creatine; Glx, summation of glutamate and glutamine.
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