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AJNR - American Journal of Neuroradiology

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Severe Diffuse Systemic Amyloidosis with Involvement of the Pharynx, Larynx, and Trachea: CT and MR Findings

R. Gilad^a, P. Milillo^c and P.M. Som^b

^a Department of Neurosurgery, Mount Sinai School of Medicine of New York University, New York, NY
^b Department of Radiology, Mount Sinai School of Medicine of New York University, New York, NY
^c Department of Radiology, Foggia University, Foggia, Italy

View larger version (75K): [in this window] [in a new window]   Fig 1. Axial noncontrast CT of the chest shows abnormally attenuated nodular breast tissue bilaterally and focal nodularity (arrows) along the right posterior pleura.

View larger version (126K): [in this window] [in a new window]   Fig 2. Noncontrast MR images show large nodular, submucosal masses along the pharyngeal walls, supraglottic larynx, and thickening of the tracheal wall with stenosis. Note the extensive involvement of the nasopharynx and oropharynx. A, Coronal T1-weighted MR image shows the pharyngeal masses (x) to have intermediate signal intensity. B, Coronal T2-weighted MR image shows the masses (x) to have low signal intensity. The signal intensities of the masses parallel those of skeletal muscle. C, Axial T2-weighted MR image shows the masses to have low signal intensity. There is marked narrowing of the laryngeal airway (arrow). D, Axial T2-weighted MR image shows marked low signal intensity thickening (arrows) of the tracheal walls.