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AJNR - American Journal of Neuroradiology

Published ahead of print on September 24, 2007
doi: 10.3174/ajnr.A0646

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Quantitative Assessment of Iron Accumulation in the Deep Gray Matter of Multiple Sclerosis by Magnetic Field Correlation Imaging

Y. Ge^a, J.H. Jensen^a, H. Lu^a, J.A. Helpern^a, L. Miles^a, M. Inglese^a, J.S. Babb^a, J. Herbert^b and R.I. Grossman^a

^a Center for Biomedical Imaging, Department of Radiology, New York University Medical Center, New York, NY
^b Department of Neurology, MS Care Center, Hospital for Joint Diseases, New York University School of Medicine, New York, NY

View larger version (79K): [in this window] [in a new window]   Fig 1. T2-weighted images (left) and MFC color maps (right) in a 29-year-old patient with MS (top row) and a 32-year-old control subject (bottom row). Note the clearly increased MFC in the deep gray matter regions on MFC maps (arrows) in the patient (B) relative to the control subject (D), though such a difference is not remarkable on conventional T2-weighted images (A, C).

View larger version (12K): [in this window] [in a new window]   Fig 2. Graph showing significant correlation of MFC in the thalamus and number of lesions in patients with relapsing-remitting MS. This trend indicates the role of white matter lesions (with axonal transection) in the accumulation of iron in deep gray matter by interruption of iron transport from the deep gray matter nuclei to the cortical regions.