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AJNR - American Journal of Neuroradiology

Published ahead of print on September 24, 2007
doi: 10.3174/ajnr.A0642

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Characteristics of Abnormal Diffusivity in Normal-Appearing White Matter Investigated with Diffusion Tensor MR Imaging in Tuberous Sclerosis Complex

M.I. Makki^a,b, D.C. Chugani^a,c, J. Janisse^d and H.T. Chugani^a,b,c

^a Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Mich
^b Department of Neurology, Children's Hospital of Michigan, Detroit, Mich
^c Department of Radiology, Children's Hospital of Michigan, Detroit, Mich
^d Center for Healthcare Effectiveness Research, Wayne State University, Detroit, Mich

View larger version (61K): [in this window] [in a new window]   Fig 1. A–D, T2-weighted image of the diffusion acquisition (A), diffusion-weighted map as an average of the 6 directions (B), ADC map (C), and FA map (D), processed from DTI acquired on a 1.5T scanner in an 8-year-old patient with TSC (6 diffusion directions, 6 averages, b = 1000 [s/mm2]).

View larger version (33K): [in this window] [in a new window]   Fig 2. A–C, Selected ROIs are carefully drawn over the FA color-encoded images (A) and pasted on the corresponding main eigenvalues maps (B) and ADC map (C). The ROIs are indexed as follows: GCC#1, SCC#2, ALIC#3, PLIC#4, and EC#5. Red arrows indicate some of the TSC lesions.

View larger version (80K): [in this window] [in a new window]   Fig 3. A–D, Selected ROIs on the FA color-encoded image (A) are pasted on the eigenvalues maps (eg, main [B], middle [C], and minor [D] eigenvalues). The ROIs are indexed as follows: GCC#1, SCC#2, ALIC#3, PLIC#4, and EC#5. Red arrows indicate some of the TSC lesions.