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AJNR - American Journal of Neuroradiology

Published ahead of print on September 24, 2007
doi: 10.3174/ajnr.A0751

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Early Postnatal Development of Corpus Callosum and Corticospinal White Matter Assessed with Quantitative Tractography

J.H. Gilmore^a, W. Lin^b, I. Corouge^c, Y.S.K. Vetsa^c, J.K. Smith^b, C. Kang^a,d, H. Gu^a,d, R.M. Hamer^a,d, J.A. Lieberman^e and G. Gerig^a,c

^a Schizophrenia Research Center and Department of Psychiatry, University of North Carolina, Chapel Hill, NC
^b Department of Radiology, University of North Carolina, Chapel Hill, NC
^c Department of Computer Science, University of North Carolina, Chapel Hill, NC
^d Department of Biostatistics, University of North Carolina, Chapel Hill, NC
^e Department of Psychiatry, Columbia University, New York, NY

View larger version (38K): [in this window] [in a new window]   Fig 1. Visualization of the 4 fiber tracts in axial and sagittal views, with overlay of location selected for statistical analysis. Genu (green), splenium (yellow), and left and right motor tracts (cyan) are shown in a 3D display combined with the DTI FA image. CS-12, central corticospinal tract; CS9, cortical corticospinal tract; G0, central genu; G21, cortical genu; S0, central splenium; S24, cortical splenium.

View larger version (30K): [in this window] [in a new window]   Fig 2. Mean diffusivity, fractional anisotropy, T1w and T2w signal intensity in the major white matter tracts of the neonate (n = 47). See "Results" for details of statistical analysis.

View larger version (40K): [in this window] [in a new window]   Fig 3. Maturation of mean diffusivity (MD) and fractional anisotropy (FA) in white matter tracts of the genu, splenium, and left corticospinal tract (n = 47). In the genu, MD was significantly correlated with age in the central (r2 = 0.2392; P = .0005) and peripheral (r2 = 0.3781; P < .0001) regions. FA also was significantly correlated with age in the central (r2 = 0.1810; P = .0029) and peripheral (r2 = 0.4219; P < .0001) regions. Unlike other fiber tracts studied, there were no significant correlations of age with MD in the central (r2 = 0.05944; P = .0986) and peripheral (r2 = 0.02135; P = .3271) regions of the splenium. In the splenium, FA also was not significantly correlated with age in the central (r2 = 0.000027; P = .9720) and peripheral (r2 = 0.00175; P = .7800) regions. In the left corticospinal tract, MD was significantly correlated with age in the central (r2 = 0.3447; P < .0001) and peripheral (r2 = 0.4727; P < .0001) regions. FA was significantly correlated with age in the central (r2 = 0.2363; P = .0005) and peripheral (r2 = 0.1138; P < .0204) regions.

View larger version (35K): [in this window] [in a new window]   Fig 4. Age-related changes in T1W and T2W signal intensity in the white matter tracts of the genu, splenium, and left corticospinal tract. In the genu, T1W signal intensity was not significantly correlated with age in either the central (r2 = 0.03823; P = .2461) or peripheral region (r2 = 0.005794; P = .6543). T2W signal intensity significantly declined with age in both the central (r2 = 0.09326; P = .0348) and peripheral regions (r2 = 0.2891; P = .0001). A similar overall pattern is present in the left corticospinal tract. T1W signal intensity was not significantly correlated with age in either the central (r2 = 0.02530; P = .3541) or peripheral region (r2 = 0.005692, P = .6619) and T2W signal intensity decreases with age in both the central (r2 = 0.5204, P < .0001.) and cortical peripheral (r2 = 0.3975; P < .0001) regions. In the splenium, a different pattern is evident. T1W signal intensity decreases with age in the central (r2 = 0.1207; P = .0352) but not the peripheral region (r2 = 0.01349; P = .4937). T2W signal intensity significantly decreased with age in the peripheral region (r2 = 0.1818; P = .0025), but not in the central region (r2 = 0.01067; P = .4848).