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AJNR - American Journal of Neuroradiology

Published ahead of print on October 18, 2007
doi: 10.3174/ajnr.A0754

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Contribution of Diffusion-Weighted Imaging in the Evaluation of Diffuse White Matter Ischemic Lesions in Fetuses: Correlations with Fetopathologic Findings

F. Guimiot^a, C. Garel^b, C. Fallet-Bianco^d, F. Menez^a, S. Khung-Savatovsky^a, J.-F. Oury^c, G. Sebag^b and A.-L. Delezoide^a

^a From the Service de Biologie du Développement, Hôpital Robert Debré, AP-HP, Paris, France
^b Service de Radiologie, Hôpital Robert Debré, AP-HP, Paris, France
^c Service de Gynécologie-Obstétrique, Hôpital Robert Debré, AP-HP, Paris, France
^d Service d’Anatomie Pathologique, Hôpital Saint-Anne, Paris, France

View larger version (186K): [in this window] [in a new window]   Fig 1. Correlation between WM MR signals and DWI abnormalities is shown on T1 (A,D,G), T2 (B,E,H), ADC map (F), and DWI (C,I) axial sections of the brains of group A and group B fetuses. A–C, Case 11 demonstrates marked diffuse T1 hypointensity and T2 hyperintensity of the WM with normal diffusion. D–F, Case 5 shows mild T1 hypointensity and T2 hyperintensity of the posterior WM with increased ADCs (2.10). G–I, Case 6 exhibits more marked T1 hypointensity and T2 hyperintensity of the anterior WM with increased diffusion.

View larger version (63K): [in this window] [in a new window]   Fig 2. Histologic analysis for cerebral edema. Histologic sections stained with H&E show the 3 degrees of cerebral edema (A–C). A, Degree 1 edema. B, Degree 2 edema (arrows indicate mild parenchymal dissociation). C, Degree 3 edema. D, A 3D graphic representation of the distribution of the 3 degrees of cerebral edema between the 2 groups. Scale bars indicate 400 µm.

View larger version (134K): [in this window] [in a new window]   Fig 3. Histologic analysis for astrogliosis. Immunohistochemical examination of astrogliosis with a GFAP-specific antibody (A–D). A, Normal astrocytic population. B, Degree 1 astrogliosis. C, Degree 2 astrogliosis (arrowheads and arrows indicate normal astrocytes and reactive astrocytes, respectively, in B and C). D, Degree 3 astrogliosis. E, A 3D graphic representation of the distribution of the 3 degrees of astrogliosis between the 2 groups. Scale bars indicate 50 µm.