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AJNR - American Journal of Neuroradiology

Published ahead of print on October 10, 2007
doi: 10.3174/ajnr.A0740

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Whole Brain and Localized Magnetization Transfer Measurements Are Associated with Cognitive Impairment in Patients Infected with Human Immunodeficiency Virus

Y. Wu^a,b, P. Storey^a,b, A. Carrillo^a, C. Saglamer^b, B.A. Cohen^d, L.G. Epstein^c,d, R.R. Edelman^a,b and A.B. Ragin^a,b

^a Department of Radiology, Evanston Northwestern Healthcare, Evanston, Ill
^b Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill
^c Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Ill
^d Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, Ill

View larger version (11K): [in this window] [in a new window]   Fig 1. A, In MTR histograms, the normalized whole brain peak for patients with HIV is lower and shifted to the left, demonstrating significantly reduced MTR value compared with that of control subjects. AU indicates arbitrary unit; asterisk, P < .05. B, Whole brain mean MTR and peak site for HIV and control subjects. Asterisk indicates P < .05; double asterisks, P < .01.

View larger version (33K): [in this window] [in a new window]   Fig 2. A, ROIs. From left to right, MT without saturation, MT with saturation, and MTR color maps. B, Group comparisons of the HIV and controls for the studied ROIs. Splen indicates splenium; CSEM, centrum semiovale; Put, putamen; Caud, caudate; Thal, thalamus; asterisk, P < .05; double asterisks, P < .01.

View larger version (29K): [in this window] [in a new window]   Fig 3. Scatterplots of significant correlations between MTR measurements and cognitive status measures, including the MSK ordinal-scale dementia rating (A–C) and continuous cognitive function variables (D–F).