AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on October 26, 2007
doi: 10.3174/ajnr.A0747
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laslo, A.M.
Right arrow Articles by Lee, T.Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laslo, A.M.
Right arrow Articles by Lee, T.Y.

CT Perfusion-Derived Mean Transit Time Predicts Early Mortality and Delayed Vasospasm after Experimental Subarachnoid Hemorrhage

A.M. Lasloa,b,c, J.D. Eastwoodd, P. Pakkiric, F. Chena,b,c and T.Y. Leea,b,c

a Imaging Division, Lawson Health Research Institute, London, Ontario, Canada
b Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
c Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
d Department of Radiology, Duke University Medical Center, Durham, NC


Figure 1
View larger version (18K):
[in this window]
[in a new window]

  		Fig 1. Graph of neurologic scores (mean ± SD) for the moderate-severe VSPdelayed group, mild VSPdelayed group, and sham group. Animals with moderate-severe VSPdelayed had greater neurologic deficit than animals with mild VSPdelayed (asterisk, P < .01) and sham animals (number sign, P < .01).


Figure 2
View larger version (151K):
[in this window]
[in a new window]

  		Fig 2. Brain stem sections. After SAH, eosinophilic neurons are evident at 24 hours (A), and by 16 days, there are astrocytes and scattered macrophages (B). There is no damage at 24 hours (C) or 16 days (D) after the sham procedure (H&E, x20).


Figure 3
View larger version (14K):
[in this window]
[in a new window]

  		Fig 3. Basilar artery diameter (mean ± SD) before SAH (baseline) and after SAH for animals with mild and moderate-severe VSPdelayed. In the mild VSPdelayed group, arterial diameter was significantly less than baseline on days 2 and 4 (number sign, P < .01 compared with baseline). In the moderate-severe VSPdelayed group, arterial diameter was significantly less than baseline 2, 4, and 7 days after SAH (asterisk, P < .01 compared with baseline).


Figure 4
View larger version (23K):
[in this window]
[in a new window]

  		Fig 4. CT perfusion measurements of MTT in the brain stem, cerebellum, parieto-occipital cerebrum, and deep gray matter. In the moderate-severe VSPdelayed group, MTT was significantly greater than both the mild VSPdelayed and sham groups (asterisk, P < .01 compared with sham; double asterisks, P < .01 compared with both mild and sham).


Figure 5
View larger version (146K):
[in this window]
[in a new window]

  		Fig 5. CT perfusion maps of MTT. MTT in an animal with mild delayed vasospasm (<24%) does not change in the brain stem (BS) or the cerebellum (CB) between baseline (A) and day 4 (B). In moderate-severe delayed vasospasm (≥24%), MTT increases from baseline (C) to day 4 (D) in the BS and CB. The white arrows show areas of increased MTT.


Figure 6
View larger version (16K):
[in this window]
[in a new window]

  		Fig 6. Scatterplot of basilar artery diameter (millimeters) versus MTT (seconds) in the brain stem. There is a significant negative correlation between MTT and basilar artery diameter (P < .05).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X