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AJNR - American Journal of Neuroradiology

Published ahead of print on October 9, 2007
doi: 10.3174/ajnr.A0752

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Relationship Between Aneurysm Volume and Histologic Healing after Coil Embolization in Elastase-Induced Aneurysms: A Retrospective Study

Y.H. Ding^a, D. Dai^a, R. Kadirvel^a, D.A. Lewis^a, H.J. Cloft^a and D.F. Kallmes^a

^a From the Department of Radiology, Neuroradiology Research Laboratory, Mayo Clinic, Rochester, Minn

View larger version (13K): [in this window] [in a new window]   Fig 1. The graph illustrates a linear regression showing a significant (P < .001) negative correlation between aneurysm volume and PD. The graph also contains the regression line (straight line) and the 95% confidence intervals (bowed lines).

View larger version (13K): [in this window] [in a new window]   Fig 2. This graph illustrates a linear regression showing a significant (P < .01) inverse relationship between the histologic healing index and the aneurysm volume. The graph also contains the regression line (straight line) and the 95% confidence intervals (bowed lines).

View larger version (37K): [in this window] [in a new window]   Fig 3. Healing in a larger aneurysm. A, DSA image before embolization shows the aneurysm cavity. B, DSA image immediately postembolization shows complete occlusion. C, DSA image before sacrifice shows that the aneurysm remains occluded. D, Staining shows that part of the aneurysm cavity is filled with unorganized thrombus (H&E, original magnification x40).

View larger version (40K): [in this window] [in a new window]   Fig 4. Healing in a smaller aneurysm. A, DSA image before embolization shows the aneurysm cavity. B, DSA image immediately postimplantation shows that the aneurysm is totally occluded. C, DSA image before sacrifice shows that the aneurysm remains completely occluded. D, Staining shows that the aneurysm dome is filled with attenuated connective tissue (H&E, original magnification x40).

View larger version (13K): [in this window] [in a new window]   Fig 5. This graph illustrates a linear regression showing a significant (P < .01) positive correlation between PD and histologic healing. The graph also contains the regression line (straight line) and the 95% confidence intervals (bowed lines).

View larger version (22K): [in this window] [in a new window]   Fig 6. A bar graph shows the relationship between PD versus histologic healing at >30% and <30%.