AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on September 3, 2008
doi: 10.3174/ajnr.A1176
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Osteoporosis Primer for the Vertebroplasty Practitioner: Expanding the Focus Beyond Needles and Cement

A.E. Kearnsa and D.F. Kallmesb

a Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minn
b Department of Radiology, Mayo Clinic, Rochester, Minn


Figure 1
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  		Fig 1. Bone remodeling sequence. A cartoon depiction of the sequential action of osteoclasts and osteoblasts to remove old bone and replace it with new bone. For simplicity of illustration, the cartoon shows remodeling in only 2 dimensions, whereas in vivo, it occurs in 3 dimensions, with osteoclasts continuing to enlarge the cavity at one end and osteoblasts beginning to fill it in at the other end. Reproduced with permission of the American Society for Bone and Mineral Research from J Bone Miner Res (2005;20:177–84).


Figure 2
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  		Fig 2. High bone remodeling is associated with increased risk of fracture in postmenopausal women. The x-axis shows lumbar spine bone mineral density (LS-BMD), the y-axis shows vertebral fracture rate (VFR), and the z-axis shows bone remodeling rate (BFR) from iliac crest bone biopsies. The peaks of fracture rate occur with low bone density and a high remodeling rate. 100p-yr indicates 100 patients per year. Reprinted with permission from Elsevier from Riggs et al.9


Figure 3
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  		Fig 3. Microstructure of normal (A) and osteoporotic (B) bone. Iliac crest bone biopsy shows normal trabecular connectivity (A) and loss of connectivity in osteoporotic bone (B). The reduction in total bone mass is also evident in osteoporotic bone (original magnification x1.25).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X