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AJNR - American Journal of Neuroradiology

Published ahead of print on August 7, 2008
doi: 10.3174/ajnr.A1242

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Analysis of ¹¹C-methionine Uptake in Low-Grade Gliomas and Correlation with Proliferative Activity

T. Kato^a,b, J. Shinoda^a, N. Oka^a, K. Miwa^a, N. Nakayama^b, H. Yano^b, T. Maruyama^c, Y. Muragaki^c and T. Iwama^b

^a Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo City, Gifu, Japan
^b Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
^c Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan

View larger version (36K): [in this window] [in a new window]   Fig 1. Standard ROI placement. Co-registration of PET and MR imaging was attempted in all cases. The tumor maximal SUV was selected as the highest accumulation in the entire tumor. Also, the mean SUV of the contralateral normal frontal cortex was drawn in 3 circular ROIs with a diameter of 10 mm on each of the 3 axial planes. Left: MET PET. Right: FLAIR image.

View larger version (12K): [in this window] [in a new window]   Fig 2. Box plots comparing MET T/N ratio in grade II gliomas. Circles above bars represent outliers (1.5 x the interquartile range). Asterisks represent the mean value. There was a significant difference between the MET T/N ratios of DA and OD (P < .005).

View larger version (74K): [in this window] [in a new window]   Fig 3. Left upper: contrast-enhanced T1WI. Right upper: FLAIR image. Left lower: MET PET. Right lower: MET PET is superimposed on contrast-enhanced T1WI. A, A 31-year-old man presented with diffuse astrocytoma that had a lower MET uptake and proliferative activity (MET T/N ratio, 1.00; Mib-1 LI, 1.1%). B, A 37-year-old man presented with diffuse astrocytoma with a higher MET uptake and proliferative activity (MET T/N ratio, 3.25; Mib-1, LI, 5.6%). C, A 35-year-old man presented with oligodendroglioma with a higher MET uptake and lower proliferative activity (MET T/N ratio, 4.71; Mib-1 LI, 3.0%).

View larger version (9K): [in this window] [in a new window]   Fig 4. Graph showing the correlation between MET T/N ratio and Mib-1 LI. A significant correlation was shown in diffuse astrocytoma (A; r = 0.63; P < .005). A correlation could not be demonstrated in oligodendroglioma (B) and oligoastrocytoma (C).