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AJNR - American Journal of Neuroradiology

Published ahead of print on September 10, 2008
doi: 10.3174/ajnr.A1253

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Abciximab for Treatment of Thromboembolic Complications during Endovascular Coiling of Intracranial Aneurysms

R.G. Jones^a, I. Davagnanam^a, S. Colley^a, R.J. West^a and D.A. Yates^a

^a From the Department of Interventional Radiology, University Hospital Birmingham, Queen Elizabeth Medical Centre, Birmingham, UK

View larger version (64K): [in this window] [in a new window]   Fig 1. A, Thrombus formation at the origin (arrowhead) and distal total occlusion (arrow) of the right PCA in association with protrusion of a coil into the parent artery on near-completion angiography during coiling of a large basilar tip aneurysm. B, Angiogram 20-minutes post-intra-arterial abciximab demonstrates restored patency of the right PCA with a small residual amount of thrombus (arrowhead) at the aneurysm neck–parent artery interface. C, Angiogram 6 months after embolization demonstrates complete exclusion of the aneurysm and arterial patency with resolution of thrombus.

View larger version (43K): [in this window] [in a new window]   Fig 2. A, Precoiling angiogram demonstrates a large basilar artery aneurysm arising in close proximity to the origin of the left anterior inferior cerebellar artery. B, Mid coil-embolization of the aneurysm with a small thrombus causing a filling defect in the parent vessel (arrowhead) and near-total occlusion of the left PCA (arrow). C, Approximately 30 minutes following the administration of an intravenous bolus of abciximab, there is demonstrable restoration of flow within the left PCA.