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AJNR - American Journal of Neuroradiology

Published ahead of print on November 1, 2007
doi: 10.3174/ajnr.A0797

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Diffusion Tensor Imaging Screening of Radiation-Induced Changes in the White Matter after Prophylactic Cranial Irradiation of Patients with Small Cell Lung Cancer: First Results of a Prospective Study

T. Welzel^a, A. Niethammer^a, U. Mende^a, S. Heiland^b, F. Wenz^c, J. Debus^a and R. Krempien^a

^a Department of Radiooncology, University of Heidelberg, Heidelberg, Germany
^b Department of Neuroradiology, University of Heidelberg, Heidelberg, Germany
^c Department of Radiooncology, University of Heidelberg, Mannheim, Germany

View larger version (19K): [in this window] [in a new window]   Fig 1. A, Change in mean fractional anisotropy in patients with 0 or 1 vascular risk factor (n = 10). *1 indicates significant reduction from baseline (P < .05); *2 indicates significant improvement from baseline (P < .05). B, Reduction of mean fractional anisotropy in patients with more than 1 vascular risk factor (n = 6). *1 indicates significant reduction from baseline (P < .05); *2 indicates further significant reduction from the end of RT (P < .05).