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AJNR - American Journal of Neuroradiology

Published ahead of print on December 7, 2007
doi: 10.3174/ajnr.A0842

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High b-Value Diffusion (b = 3000 s/mm²) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm²

H.S. Seo^a,b, K.-H. Chang^a, D.G. Na^a, B.J. Kwon^a and D.H. Lee^a

^a Department of Radiology, Seoul National University School of Medicine
^b Department of Radiology, Dongguk University International Hospital, Seoul, Korea

View larger version (121K): [in this window] [in a new window]   Fig 1. Grade IV glioblastoma in a 27-year-old man. A, Transverse T2-weighted image shows a slightly hyperintense main mass (arrow) in the right medial temporal lobe. B, Sagittal contrast-enhanced T1-weighted image shows diffuse tumor enhancement (arrow). C, Transverse DWI at b = 1000 s/mm2 shows slight tumor hyperintensity with some hypointense foci. D, Transverse DWI at b = 3000 s/mm2 shows more conspicuous main mass hyperintensity. E, Transverse ADC map at b = 1000 s/mm2 shows subtle or slight tumor hypointensity. F, Transverse ADC map at b = 3000 s/mm2 shows more conspicuous tumor hypointensity.

View larger version (136K): [in this window] [in a new window]   Fig 2. Grade II diffuse astrocytoma in a 66-year-old man. A, Transverse T2-weighted image shows a hyperintense mass (arrow) in the left medial temporal lobe. B, Coronal contrast-enhanced T1-weighted image shows slight tumor hypointensity without enhancement (arrow). C, Transverse DWI at b = 1000 s/mm2 shows tumor isointensity. D, Transverse DWI at b = 3000 s/mm2 shows marked tumor hypointensity. Transverse ADC maps at b = 1000 s/mm2 (E) and b = 3000 s/mm2 (F) show tumor hyperintensity.

View larger version (11K): [in this window] [in a new window]   Fig 3. ROC curves derived from 5-point scale visual assessment scores at b = 1000 and 3000 s/mm2. The Az value of DWI at b = 3000 s/mm2 was higher than at b = 1000 s/mm2 but this was not statistically significant (0.864 vs 0.790; P =.08).

View larger version (12K): [in this window] [in a new window]   Fig 4. Box plots of DWI SI ratios (A) in high-grade and low-grade gliomas, and ADC values (B) of high-grade and low-grade gliomas and normal subcortical white matter at b = 1000 and 3000 s/mm2. The horizontal line is the median, and the upper and lower ends of the boxes are the upper and lower quartiles, respectively. The vertical lines represent data ranges. A, The mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values (P < .01). Note that the difference between the mean SI ratios of high-grade and low-grade gliomas at b = 3000 s/mm2 was significantly greater than at b = 1000 s/mm2 (P < .05). B, The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values (P < .01). The mean ADC values of high-grade and low-grade gliomas and normal subcortical white matter at b = 3000 s/mm2 were significantly lower than at b = 1000 s/mm2, respectively (P < .01).