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AJNR - American Journal of Neuroradiology

Published ahead of print on December 7, 2007
doi: 10.3174/ajnr.A0872

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Primary Cerebral Lymphoma and Glioblastoma Multiforme: Differences in Diffusion Characteristics Evaluated with Diffusion Tensor Imaging

C.-H. Toh^a, M. Castillo^c, A.M.-C. Wong^a, K.-C. Wei^b, H.-F. Wong^a, S.-H. Ng^a and Y.-L. Wan^a

^a Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
^b Department of Neurosurgery, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Tao-Yuan, Taiwan
^c Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC

View larger version (57K): [in this window] [in a new window]   Fig 1. ADC and FA measurements in a 22-year-old man with pathologically confirmed lymphoma in the right temporo-occipital region. A, Axial contrast-enhanced T1-weighted MR image (781/8.1) shows an enhancing mass in the right temporo-occipital region. There are enhancing nodules along the right frontal ependymal surface. There is a rim-enhancing nodule posteromedial to the main mass; cystic change or necrosis of the tumor is considered. One ROI is in the enhancing tumor area for measurement of ADC and FA values, and another ROI is at a corresponding site in the contralateral NAWM. On FA (B) and ADC (C) maps, the ROIs in A are superimposed.

View larger version (52K): [in this window] [in a new window]   Fig 2. ADC and FA measurements in a 45-year-old woman with pathologically confirmed GBM in the left frontal region. A, Axial contrast-enhanced T1-weighted MR image (350/2.5) shows an enhancing mass in the left frontal region. One ROI is in the enhancing tumor area for measurement of ADC and FA values, and another ROI is at a corresponding site in the contralateral NAWM. On FA (B) and ADC (C) maps, the ROIs in A are superimposed.

View larger version (29K): [in this window] [in a new window]   Fig 3. Scatterplot of FA versus ADC measured in solid enhancing tumors and contralateral NAWM. Measurements from lymphomas tend to cluster in the area corresponding with FA and ADC decreases, whereas measurements from GBMs tend to cluster in area corresponding with FA decreases and ADC increases.