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AJNR - American Journal of Neuroradiology

Published ahead of print on January 17, 2008
doi: 10.3174/ajnr.A0850

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Altered Diffusion in the Frontal Lobe in Parkinson Disease

A.T. Karagulle Kendi^a, S. Lehericy^b, M. Luciana^c, K. Ugurbil^a and P. Tuite^d

^a Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, Minn
^b Center for NeuroImaging Research, INSERM U610, Pitie-Salpetriere Hospital, University Pierre and Marie Curie, Paris, France
^c Department of Psychology, University of Minnesota, Minneapolis, Minn
^d Department of Neurology, University of Minnesota, Minneapolis, Minn

View larger version (104K): [in this window] [in a new window]   Fig 1. Axial FA (A) and MD (B) images of a control subject at the level of the basal ganglia.

View larger version (26K): [in this window] [in a new window]   Fig 2. A, A glass brain showing significant clusters of reduced FA in patients with PD compared with control subjects as viewed from the right (upper left), front (upper right), and above (lower left). SPM display is according to radiologic convention (right-to-left orientation). B, The statistical map is superimposed on the normalized average FA image. The images are in MNI space. Color bar indicates z-score. Clusters were considered significant at P < .05, corrected for multiple comparisons.