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AJNR - American Journal of Neuroradiology

Published ahead of print on January 9, 2008
doi: 10.3174/ajnr.A0900

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A Whole-Brain Analysis in De Novo Parkinson Disease

C. Tessa^a, M. Giannelli^c, R. Della Nave^d, C. Lucetti^b, C. Berti^b, A. Ginestroni^d, U. Bonuccelli^b and M. Mascalchi^d

^a Radiology Unit, Versilia Hospital, Lido di Camaiore, Lucca, Italy
^b Department of Neuroscience, University of Pisa, Pisa, Italy
^c Medical Physics Unit, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
^d Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, Florence, Italy

View larger version (15K): [in this window] [in a new window]   Fig 1. Scatterplots showing the distribution of the GM (A) and WM (B) volumes and of the twenty-fifth (C), fiftieth (D), and seventy-fifth (E) percentiles of the whole-brain FA histogram in the healthy controls and in the subgroups of patients with PD including those with tremor-dominant type (TDT), akinetic-rigid type (ART), and mixed type (MT).

View larger version (15K): [in this window] [in a new window]   Fig 2. Averaged whole-brain FA histograms in healthy controls (dashed line) and the whole group of patients with PD (continuous line). Note the right shift of the FA histogram curve in patients with PD, implying higher anisotropy values, and its lower asymmetry (skewness) with respect to the curve of the controls.