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AJNR - American Journal of Neuroradiology

Published ahead of print on January 9, 2008
doi: 10.3174/ajnr.A0912

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Brain Metabolite Levels Assessed by Lactate-Edited MR Spectroscopy in Premature Neonates with and without Pentobarbital Sedation

Z.J. Wang^a, D.B. Vigneron^a, S.P. Miller^a,b, P. Mukherjee^a, N.N. Charlton^a, Y. Lu^a and A.J. Barkovich^a,b,c

^a Department of Radiology, University of California San Francisco, San Francisco, Calif
^b Department of Pediatrics, University of California San Francisco, San Francisco, Calif
^c Department of Neurology, University of California San Francisco, San Francisco, Calif

View larger version (24K): [in this window] [in a new window]   Fig 1. Location of the voxels and normal neonatal proton spectra obtained at a gestation age of 32 weeks from a prematurely born infant. The infant received pentobarbital sedation. A, The basal ganglion voxel includes the head of caudate and the anterior putamen (black box, left). The thalamic voxel is indicated by the white box in the left image. The corticospinal tract voxel includes the corticospinal tract within the centrum semiovale (white box, right). B, Lactate-edited spectra. Top row shows the summed spectra in each voxel for Cho, Cr, and NAA. The bottom row shows the difference spectra for each voxel; the difference spectra show only the Lac peaks. Cho indicates choline; Cr, creatine; Lac, lactate.