AJDRAJNR - American Journal of Neuroradiology

Published ahead of print on February 13, 2008
doi: 10.3174/ajnr.A0970
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Extent of Microstructural White Matter Injury in Postconcussive Syndrome Correlates with Impaired Cognitive Reaction Time: A 3T Diffusion Tensor Imaging Study of Mild Traumatic Brain Injury

S.N. Niogia, P. Mukherjeeb, J. Ghajarc,d, C. Johnsone, R.A. Kolstera,c, R. Sarkarc, H. Leef, M. Meekerf, R.D. Zimmermane, G.T. Manleye and B.D. McCandlissa

a Department of Psychiatry, Sackler Institute, Weill Medical College of Cornell University, New York, NY
b Department of Radiology, University of California, San Francisco, San Francisco, Calif
c Brain Trauma Foundation, New York, NY
d Department of Neurological Surgery, Weill Medical College of Cornell University, New York, NY
e Department of Radiology, Weill Medical College of Cornell University, New York, NY
f Department of Neurological Surgery, University of California, San Francisco, Calif


Figure 1
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  		Fig 1. Region-of-interest placement for DTI analysis. Shown are corresponding regions of interest for the right hemisphere. The solid ellipse within the white outline indicates the location and size of the region of interest. A, Middle cerebral peduncle. B, Pontine crossing tract. C, Superior cerebellar peduncle. D, Decussation of the superior cerebellar peduncle. E, Cerebral peduncle. F, Anterior inferior longitudinal fasciculi. G, Posterior inferior longitudinal fasciculi. H, Uncinate fasciculus. I, Genu of the corpus callosum. J, Forceps minor. K, Forceps major. L, Posterior limb of the internal capsule. M, Anterior limb of internal capsule. N, Splenium of the corpus callosum. O, Body of the corpus callosum. P, Superior corona radiata. Q, Anterior corona radiata. R, Superior longitudinal fasciculus at level of the body of the corpus callosum. S, Superior longitudinal fasciculus at level of cingulum bundle. T, Cingulum bundle. U, Anterior centrum semiovale. V, Posterior centrum semiovale. Regions of interest were placed on both cerebral hemispheres when applicable, resulting in a total of 39 regions of interest per subject.


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  		Fig 2. A, Correlation of the number of damaged white matter tracts and speed of processing. The correlation is statistically significant (P = .012) with r = 0.49. B, In contradistinction, the corresponding analysis, by using conventional MR imaging of the number of traumatic microhemorrhages correlated with speed of processing, is not statistically significant (r = –0.08, P = .70).





Copyright © 2009 by the American Society of Neuroradiology. Print ISSN: 0195-6108 Online ISSN: 1936-959X