Advanced

AJNR - American Journal of Neuroradiology

Published ahead of print on April 10, 2008
doi: 10.3174/ajnr.A1039

This Article Abstract Full Text Full Text (PDF) Supplemental Online Tables Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Google Scholar Articles by Silvennoinen, H.M. Articles by Hunter, G.J. PubMed PubMed Citation Articles by Silvennoinen, H.M. Articles by Hunter, G.J.

CT Perfusion Identifies Increased Salvage of Tissue in Patients Receiving Intravenous Recombinant Tissue Plasminogen Activator within 3 Hours of Stroke Onset

H.M. Silvennoinen^a, L.M. Hamberg^d, P.J. Lindsberg^b,c, L. Valanne^a and G.J. Hunter^d

^a Department of Radiology-Neuroradiology, Helsinki University Central Hospital, Helsinki, Finland
^b Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland
^c Program of Molecular Neurology, University of Helsinki, Helsinki, Finland
^d Departments of Neuroradiology and Radiology, Division of Imaging, University of Texas MD Anderson Cancer Center, Houston, Tex

View larger version (122K): [in this window] [in a new window]   Fig 1. A 66-year-old patient who had right hemiparesis and underwent CTP after 65 minutes from stroke onset. Presented are maps from 2 adjacent levels as examples of reversal or decrease of CBV abnormal area. The patient was treated with intravenous thrombolysis. A, Baseline noncontrast CT. B, MTT map. C, CBF map. D, CBV map. E, Follow-up CT. F–J, Images from the next level, respectively. There is a single small infarct (arrow) seen only on 1 section at follow-up.

View larger version (31K): [in this window] [in a new window]   Fig 2. Scatter diagrams show initial lesion volume (milliliters) obtained by region-of-interest analysis of CBV, CBF, and MTT maps versus infarct size (mL) assessed on the follow-up (FU) CT scan. A and B, MTT lesion volumes in treated (A) and nontreated (B) cohorts. Presented are the regression line, 95% confidence bands, and the coefficient of determination (R2). C and D, CBF lesion volumes in treated (A) and nontreated (B) cohorts. Presented are the regression line, 95% confidence bands, and the coefficient of determination. E and F, CBV lesion volumes in treated (A) and nontreated (B) cohorts. Presented are the regression line, 95% confidence bands, and the coefficient of determination. IV indicates intravenous.

View larger version (18K): [in this window] [in a new window]   Fig 3. Scatter diagram and line of regression for correlation between lesion volumes (milliliters) measured on the MTT and CBF maps. The coefficient of determination (R2) was 0.963, and the null hypothesis that the regression line had a slope of unity was accepted (P > .2). The 95% confidence bands are very close to the regression line, and the line of unity falls within them.