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AJNR - American Journal of Neuroradiology

Published ahead of print on April 3, 2008
doi: 10.3174/ajnr.A1008

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Metabolic Assessment of Gliomas Using ¹¹C-Methionine, [¹⁸F] Fluorodeoxyglucose, and ¹¹C-Choline Positron-Emission Tomography

T. Kato^a,b, J. Shinoda^a, N. Nakayama^b, K. Miwa^a, A. Okumura^a, H. Yano^b, S. Yoshimura^b, T. Maruyama^c, Y. Muragaki^c and T. Iwama^b

^a Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo City, Gifu, Japan
^b Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu, Japan
^c Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan

View larger version (16K): [in this window] [in a new window]   Fig 1. Graph showing the correlation between tracer uptake and tumor grade. *P < .05, P < .01, P < .001.

View larger version (90K): [in this window] [in a new window]   Fig 2. Left top, Contrast-enhanced, T1-weighted image. Right top, MET PET is superimposed on MR imaging. Left bottom, CHO PET is superimposed on MR imaging. Right bottom, FDG PET is superimposed on MR imaging. A, A 32-year-old woman presented with diffuse astrocytoma. MET T/N ratio = 1.72, CHO T/N ratio = 1.38, and FDG T/N ratio = 0.66. B, A 23-year-old woman presented with oligoastrocytoma. MET T/N ratio = 2.76, CHO T/N ratio = 1.82, and FDG T/N ratio = 0.92. C, A 44-year-old man presented with oligodendroglioma. MET T/N ratio = 3.71, CHO T/N ratio = 2.74, and FDG T/N ratio = 1.07. D, A 62-year-old woman presented with anaplastic astrocytoma. MET T/N ratio = 4.26, CHO T/N ratio = 10.17, and FDG T/N ratio = 1.24. E, A 68-year-old man presented with glioblastoma multiforme. MET T/N ratio = 6.85, CHO T/N ratio = 33.38, and FDG T/N ratio = 2.55.

View larger version (12K): [in this window] [in a new window]   Fig 3. Graph showing the correlation between MET T/N ratio and FDG T/N ratio (r = 0.67; P < .001), CHO T/N ratio and FDG T/N ratio (r = 0.73; P < .001), and MET T/N ratio and CHO T/N ratio (r = 0.75; P < .001) in all of the gliomas.

View larger version (9K): [in this window] [in a new window]   Fig 4. Graph showing the correlation between Mib-1 LI and MET T/N ratio (r = 0.64; P < .001), FDG T/N ratio (r = 0.71; P < .001), and CHO T/N ratio (r = 0.64; P < .001) in ATs.